It’s time for a targeted option to change how generalized myasthenia gravis (gMG) is treated.

Start at the beginning: here are some important facts about gMG:

Now that we’ve covered the basics, let’s dive deeper and talk about how gMG works in the body.

In people who have gMG, the part of the immune system called the complement system doesn’t work correctly. Instead of helping the body fight off sickness by attacking intruders like bacteria and viruses, it attacks muscle cells right at the spot where the nerve meets the muscle, called the neuromuscular junction.

Damage at the neuromuscular junction makes it difficult for the muscles to get signals from the brain. The result is muscle weakness, the main symptom of gMG. That muscle weakness becomes worse as the muscle is used, and then may get better after the muscle is rested. The muscles affected can include those that control the:

Eyes

Limbs

Respiratory System

When the respiratory system is affected, it can cause a life-threatening crisis and may require treatment in a hospital or intensive care unit.

There are treatments that can help.

Our commitment to gMG doesn’t end with research.

The men and women who work at Ra are dedicated to the gMG community, and in particular, our partners at the Myasthenia Gravis Foundation of America (MGFA). We are working to spread awareness of the disease by participating in local fundraising walks and events, and by providing information about our work on the disease that can be easily shared.

Download our patient factsheet