Myasthenia gravis, or MG, is a rare, complement-mediated, autoimmune disease that causes weakness in the skeletal muscles. Patients with MG present with muscle weakness that characteristically becomes increasingly severe with repeated use and recovers with rest.
Immune-mediated necrotizing myopathy, or IMNM, is an autoimmune myopathy characterized by skeletal muscle necrosis, severe proximal limb weakness, and elevated creatine kinase levels. In IMNM, distinct autoantibodies, anti-HMGCR and anti-SRP, drive complement-mediated necrosis of muscle fibers, resulting in severe, progressive, and debilitating proximal muscle weakness.
Amyotrophic lateral sclerosis, or ALS, is the most prevalent adult-onset progressive motor neuron disease. ALS causes the progressive degeneration of motor neurons, resulting in progressive muscle weakness and atrophy that eventually lead to partial or total paralysis.