Open Positions

Director of IT

COMPANY OVERVIEW:

Ra Pharmaceuticals, Inc. (NASDAQ: RARX), is a clinical stage biotechnology company focused on development of novel therapeutics for the treatment of serious diseases that are caused by dysregulation of the complement system, a critical component of the immune system. Ra Pharma combines its expertise in the area of complement biology with leadership in macrocycle peptide technology to discover and develop therapeutics that transform the lives of patients with life threatening disorders.

We are seeking a seasoned IT Director to lead our IT Strategy, direct the planning and implementation of enterprise information systems to support R&D and general business operations.  This role will is responsible for managing all IT costs, internal IT Staff, and all outsourced IT services.  The ideal candidate will have exposure to Applications and Infrastructure needed to support a Discovery and Development stage biotech and the ability to oversee service providers in the delivery of IT Infrastructure Services.

RESPONSIBILITIES / DUTIES:

Strategy & Planning

  • Coordinate the evaluation, deployment, and management of current and future IT systems across the organization.
  • Develop and maintain an appropriate IT organizational structure that supports the needs of the business.
  • Establish IT departmental goals, objectives, and operating procedures.
  • Identify opportunities for the appropriate and cost-effective investment of financial resources in IT systems and processes, including staffing, sourcing, purchasing, and in-house development.
  • Review and negotiate hardware and software acquisition and maintenance contracts; and pursue master agreements to capitalize on economies of scale
  • Develop, track, and control the information technology annual operating and capital budgets.
  • Develop business case justifications and cost/benefit analyses for IT spending and initiatives.
  • Assist other business units in the protection and management of information assets, and the selection and implementation of information acquisition and management processes and non-IT systems.

Applications Management

  • Approve, prioritize, and control projects and the project portfolio as they relate to the selection, acquisition, development, and installation of major information systems.
  • Support Discovery and Development business partners in their use of information technologies
    • Implement research and development system projects, directing development, release and maintenance activities.
    • Develop strategic plans for progressing of key R&D initiatives including Clinical Data Management, Laboratory Information Management, Quality Systems and Electronic Lab Notebooks.

Operational Management

  • Ensure continuous delivery of IT services through oversight of service providers, oversight of service level agreements with end users, and monitoring of IT systems performance.
  • Ensure IT system operation adheres to applicable FDA, SEC, and other applicable laws and regulations.
  • Assess and work to mitigate risk across the company related to information technology and usage.
  • Keep current with trends and issues in the IT industry, including current technologies and prices. Advise, counsel, and educate executives and management on their competitive or financial impact.
  • Supervise recruitment, development, management, retention, and organization of all IT staff in accordance with corporate budgetary objectives and personnel policies.
  • Other duties as assigned.

QUALIFICATIONS:

REQUIRED

  • Bachelor’s degree in Computer Science, Information Systems or related field
  • 5 years of IT management experience
  • Strong project management skills; experience in organizing, planning and executing projects from vision through implementation, involving internal personnel, contractors and vendors; ability to analyze project needs and determine resources needed to meet objectives
  • Knowledge of pharmaceuticals business practices and direction including research and development
  • Strong communicator with ability to maintain open communication with internal employees, managers and customers as needed
  • Able to integrate and apply feedback in a professional manner
  • Able to prioritize and drive to results with a high emphasis on quality
  • Ability to work as part of a team

DESIRED

  • Experience with managing IT Infrastructure Service Providers
  • Strong practical experience in the planning, implementation and ongoing support of Applications and Infrastructure to support Discovery and Development environments at a clinical-stage Biotech

 

 

Scientist, Biology

Job Code: TB201

We are currently seeking a highly skilled and motivated individual with a strong background in immunology to join the Biology team as a Scientist. Expertise in innate and adaptive (T cell) immunity, immune cell-endothelial cell interactions, and knowledge of autoimmune and inflammatory diseases is preferred. The candidate will be responsible for the design, execution and establishment of cell-based assays as well as development of in vitro and animal disease models to validate therapeutic targets and demonstrate efficacy of lead compounds. The candidate will also provide translational biology support to programs as they progress through clinical development.

Qualifications: The ideal candidate will have a PhD in Immunology or closely-related field.  Postdoctoral work experience in immunology is preferred. Extensive hands-on experience in immunological cellular techniques including isolation and characterization of primary immune cells from human and animal tissues is required. The ideal candidate will have cell-based and biochemical assay development experience using technologies such as multicolor flow cytometry, ELISA, immunofluorescence, and microfluidics tools for assaying immune cell function. The successful candidate must be able to thrive and develop in a fast-paced and dynamic team environment, to complete tasks with a sense of urgency, and to have a passion for scientific excellence.

Requirements:

  • PhD in Immunology or a related field, with minimum of 2 years postdoctoral work preferred with proven track record of success
  • Research experience in autoimmune and inflammatory diseases
  • Extensive hands-on experience in immune cell isolation and characterization, multi-color flow cytometry, immune cell activation assays, and tissue culture
  • Ability to independently design, execute, and analyze experiments
  • Strong multi-tasking skills
  • Excellent communication, presentation, collaboration and organizational skills

To apply, please send resume and cover letter to hr@rapharma.com.

Synthetic / Medicinal Chemist

Job Code: MC2018

Our Medicinal Chemistry team is currently seeking an experienced, innovative chemist with the ability to generate and implement original ideas and contribute to the success of the team.  We are seeking a creative, energetic, and results-oriented individual, who possesses a track record of success. This individual will join a medicinal chemistry team and be required to perform synthetic organic chemistry in the laboratory at a high level as well as design and data analysis of targets and routes. The candidate will be expected to work independently as part of a collaborative research team.

Responsibilities and Expectations:

  • Multi-step organic syntheses of challenging medicinal chemistry targets within a project and documentation of experimental procedures
  • Proficiency in designing, executing and troubleshooting multi-step syntheses
  • Analysis of complex data sets and creation of design hypotheses
  • Outstanding leadership, interpersonal, communication, and time-management skills are essential
  • Active participation in discussions in medicinal chemistry team meetings to build and understand structure-activity relationships

Minimum Education & Experience Requirements: 

  • Ph.D. in synthetic organic chemistry, 0-5 years of industrial experience or M. Sc. with more than 10 years.
  • Demonstrated capabilities in modern methods of synthesis and analysis
  • Knowledge of operation of standard laboratory instrumentation (NMR, LC-MS purification and analysis, chromatography)
  • Application of structure based drug design leading to advanced leads/ development candidates
  • Strong working knowledge of protein-small molecule interactions, conformational and structural analysis, experienced working closely with computational chemists and the use of computational and visualization tools
  • Good understanding of key ADME, biochemical and pharmacological principles and capable of effectively integrating these concepts into the optimization of lead compounds

Please send resume to hr@rapharma.com.

Research Associate Analytical Development

JOB CODE: PD22018

Ra Pharmaceuticals, Inc. (NASDAQ: RARX), is a clinical stage biotechnology company focused on development of novel therapeutics for the treatment of serious diseases that are caused by dysregulation of the complement system, a critical component of the immune system. Ra Pharma combines its expertise in the area of complement biology with leadership in macrocycle peptide technology to discover and develop therapeutics that transform the lives of patients with life threatening disorders.

Description:  We are currently seeking a resourceful and motivated individual to join our team as an Associate Scientist or Scientist.  This candidate will have a supportive role in Analytical Development and will apply his/her knowledge to manage/review reference standard/stability analysis, develop analytical methods, and design experiments.  This person will also be responsible for supporting in-house analytical requirements including, but not limited to, solubility screening, forced degradation studies, small molecule and peptide purification, non-GMP stability studies and formulation development studies, and materials release.   Based upon experience, the candidate may oversee outsourced analytical method development, technical transfers, reference standard certification, GMP stability studies and material release.

Qualifications: The ideal candidate will have a BS/MS in Analytical or Organic chemistry or a closely related field and 3-5+ years of industry experience in analytical development or quality control/stability program with a proven track record of strong knowledge in stability program and developing and troubleshooting analytical methods.  Previous experience in managing/reviewing stability studies and reference standards data, characterizing and quantifying peptides, analytical method validation is preferred.  The successful candidate must be able to thrive and develop in a dynamic biotechnology start-up environment, to complete tasks with a sense of urgency, and to have a passion for scientific excellence.

Requirements:

  • BS/MS in Analytical or Organic chemistry or a related field
  • 3 to 5+ years of industry experience
  • Experience with GMP stability data review, peptides, small molecule and/or protein analytical method development including:
    • HPLC and UPLC methodology (reverse phase, size exclusion, ion exchange)
    • GC Methodology
    • Mass Spectroscopy (Quad, Q-tof and Q-Exactive).
    • Preparative Chromatography
    • QC wet chemistry
  • General familiarity with USP and EP compendial methods
  • Drive to solve problems and ability to work independently
  • Strong multi-tasking skills.
  • Excellent communication and writing skills

To apply, please send resume and cover letter to hr@rapharma.com.

Director of Bioanalytical Sciences

Job Code: DNCD2018

Company Description

Ra Pharmaceuticals (NASDAQ RARX), a clinical-stage biopharmaceutical company based in Cambridge MA, is focused on the discovery, development and commercialization of novel therapeutics based on its proprietary peptide chemistry platform.  Ra is developing therapeutics to treat serious diseases that are caused by excessive or uncontrolled activation of the complement system, a critical component of the immune system.  Ra Pharmaceuticals is assembling a team of highly motivated and experienced professionals who are committed to improving the lives of patients and building a world class biotechnology company.

Position Description

We are currently seeking a Director of Bioanalytical Sciences to lead the development and implementation of bioanalytical assays to support the entire Ra portfolio, from early discovery through clinical trials and registration. Working closely with the Research, Nonclinical Development, and Clinical Development groups, the successful candidate will assist in the development of assays to support the Ra’s novel small molecule and peptide therapies.  Primary responsibilities will include management of the in-house bioanalytical lab, method development, and the management of outsourced validated assays to support pivotal nonclinical and clinical studies. The ideal candidate will be responsible for developing and implementing the overall bioanalytical strategy to support the Ra pipeline, and will serve as the bioanalytical representative on multidisciplinary drug development teams. Candidates should be self-motivated with experience working and leading in a highly collaborative cross-functional environment.

Job Responsibilities:

  • Develop and implement the overall bioanalytical strategy to support the Ra pipeline and manage resources and 3rd party vendors as appropriate
  • Design, execute, and oversee bioanalytical assays to support small molecule and peptide discovery programs
  • Interact with multidisciplinary teams (including chemists, biologists, toxicologists, and clinical managers) to meet project goals and timelines.
  • Design and oversee GLP-regulated bioanalytical method development, validation, and sample analysis
  • Address and resolve scientific issues arising in drug discovery/development programs.
  • Serve as a subject matter expert for bioanalytical sciences and the regulatory aspects of assay development to support GLP nonclinical studies and clinical trials
  • Manage the in-house bioanalytical laboratory

Requirements

  • Ph.D. in pharmacology, biochemistry, chemistry or a related discipline and a minimum of 5-7 years of experience providing bioanalytical support for research and development teams
  • Experience developing LC/MS and ELISA-based assays in support of small molecule and biologic programs
  • Experience developing assays to support GLP-regulated nonclinical studies.
  • Familiarity with GLP regulations and experience managing and auditing bioanalytical CROs.
  • Matrix leadership or direct line management experience preferred
  • Able to solve technical problems with enthusiasm in a team environment
  • Good written and oral communication skills
  • Ability to thrive and develop in a biotechnology culture

Please send resume and cover letter to hr@rapharma.com