Open Positions

Staff Accountant

Job Code FSA2017

Ra Pharmaceuticals, Inc. (NASDAQ: RARX), is a clinical stage biotechnology company focused on development of novel therapeutics for the treatment of serious diseases that are caused by excessive or uncontrolled activation of the complement system, a critical component of the immune system. Ra Pharma combines its expertise in area of complement with leadership in macrocycle peptide technology to discover and develop therapeutics that transform the lives of patients with life threatening disorders.

Description:

The staff accountant will be a key contributor in building a dynamic accounting operations and finance organization dedicated to financial integrity and focused on supporting our growth strategy.

Responsibilities:

  • General Ledger:
    • Assist with the month end close process.
    • Input journal entries into general ledger system, which includes the preparation and submission of supporting documentation and work papers.
    • Prepare monthly account reconciliations, primarily related to prepaid expenses, fixed assets, goodwill, intangibles, accounts payable, and other assets and liabilities, as needed.
    • Assist with monthly/quarterly internal and external reporting requirements.
  • Fixed Assets:
    • Maintain fixed asset records and associated general ledger accounts
    • Ensure compliance with fixed asset policies and procedures for US GAAP
    • Record fixed asset acquisitions and dispositions and assign appropriate depreciation lives and methods to each asset
    • Prepare monthly fixed asset reports and reconciliations
  • Accounts Payable:
    • Maintain vendor listing up to date and accurate.
    • Responsible for data entry of vendor invoices in compliance with company policies & procedures.
    • File all open and paid invoices in order set up by department.
    • Assist with the pay cycle, including matching invoices, acquiring proper check signatures and distribution, and compile invoices in prep for weekly check printing cycle.
    • Improve overall processes as needed.
  • General:
    • Assist in preparation of schedules for external auditors.
    • Ensure responsibilities performed in accordance with SOX and internal control requirements
    • Perform ad-hoc analysis and other job related duties as assigned

Requirements:

The ideal candidate will be a motivated self-starter with a strong work ethic and the ability to work well in a team environment. The position requires a deadline-driven individual with attention to detail who can handle confidential information sensitively.

  • Bachelor’s degree in accounting or finance.
  • 1+ years of relevant accounting experience, including accounts payable processing and GL reconciliations.
  • Knowledge of US GAAP and relevant accounting and financial concepts.
  • Possess ability to provide clear, concise and appropriate documentation of work performed, issues and observations. This role requires significant attention to detail. Candidate should be able to collect, analyze and interpret data to produce accurate reporting.
  • Possesses “can do” attitude and willingness to roll-up sleeves.
  • Experience with NetSuite highly preferred.
  • Strong computer skills – MS Office (Excel, Word and PowerPoint)

PERSONAL CHARACTERISTICS

  • Unquestionable integrity and personal ethics.
  • Sound business judgment.
  • Ability to listen, negotiate, guide and facilitate.
  • Ability operate effectively in a team-oriented business.
  • Tireless work ethic. Must be tenacious, with the emotional intelligence to know when to look for alternative approaches.
  • Confident and self-aware with excellent interpersonal and communication skills, both written and verbal. Capable of quickly establishing credibility.
  • Intelligent, with excellent analytical and strategic skills. Good business judgment and problem solving skills.
  • Extremely well organized and objective oriented.
  • Excellent relationship building and communication skills and the ability to work effectively in a team environment.

Salary and Title commensurate with experience. Please submit cover letter and resume to hr@rapharma.com.

Director, Discovery Biology

Job Code DDB2017

Ra Pharmaceuticals is a growing biotech company headquartered in Cambridge, MA. Ra is focused on novel therapeutics for dysfunction of the Complement cascade in rare diseases. The company was founded on a macrocyclic peptide platform although the pipeline has matured to include other molecular approaches to inhibition of the complement system.

Ra Pharmaceuticals is currently seeking an experienced, innovative immunologist to lead discovery-stage biology programs focused on disorders of the immune system. A strong background in immune system disorders and underlying biology as well as management experience in a drug discovery setting is required. The ideal candidate will be a creative thinker with strong scientific background who is highly motivated to contribute in a collaborative research environment to achieve company level goals.

Responsibilities:

  • Drive innovative scientific exploration for all biology efforts from discovery stage to clinical candidate selection across all programs
  • Leadership of target identification and validation efforts for indications of interest
  • Management of hit-to-lead optimization efforts for multiple discovery stage programs
  • Spearhead internal efforts and management of collaborations with KOLs in the design of assays to conduct exploratory studies aimed at identifying novel opportunities for the use of Ra’s therapeutic molecules
  • Provide scientific support for translational sciences program by designing novel assays and development and transfer of assays to external vendors

Qualifications:

  • Ph.D. in biology or related field with a demonstrated expertise in immunology and a minimum of 10 years of experience in a drug discovery setting
  • Demonstrated success in hiring, management and development of 5 or more direct reports
  • Experience working on cross-functional project teams as a team member and/or project leader
  • Demonstrated ability to deliver on multiple projects in parallel
  • Strong communication skills and attention to detail

(Compensation will be commensurate with qualifications and experience.)

To apply, please send your résumé and cover letter to hr@rapharma.com.

Sr Dir/Dir/Associate Dir, CMC Program Management

Job Code CMCPM 2017

Ra Pharmaceuticals is looking to strengthen its Pharmaceutical Development team with the addition of a CMC Program Manager. Ra is a growing biotech company headquartered in Cambridge Boston. Focused on novel therapeutics for rare diseases, Ra employs both macrocyclic peptides and traditional small molecules to address dysfunction of the Complement cascade.

The pipeline at Ra Pharmaceuticals encompasses; RA101495, a macrocyclic peptide inhibitor of C5 currently entering phase II; an extended release version of RA101495; Factor D inhibitors for rare systemic renal disorders and dry AMD; as well as two projects in lead identification / lead optimization (C1 inhibitor and C5 oral small molecule)

As the pipeline matures we are looking to strengthen our Pharmaceutical Development group by recruiting key leadership and providing project management. We are currently recruiting for a motivated individual to join the team and lead CMC Project Management. The ideal candidate is expected to have a strong project management expertise, be able to lead through influence and motivate teams and external vendors to keep on task.

The CMC Program Manager will work closely with CMC teams, a diverse network of vendors and Program Teams to ensure achievement of deliverables, communication of project goals and expectations as well as help drive decision making, identify resource limitations, help minimize impact on timelines and maintain the development budget.

Responsibilities:

  • Serve as an integral CMC team member across multiple development projects to achieve development, manufacturing and project goals
  • Work collaboratively with CMC functions (Early Development, Analytical Development, Drug Substance Development, Drug Product Development, Supply Chain, Quality Control, Quality Assurance, and Regulatory) to ensure strong, clear communication to identify, avoid or address issues in Pharmaceutical Development and Manufacturing
  • Effectively communicate with team members, senior leaders and key stakeholders on the status, objectives, risks, and mitigation plans associated with the various CMC projects, as well as ensure CMC teams are aware of current integrated program timelines
  • Work with vendor network to maintain relations, to address conflicts in thoughtful and productive manner, negotiate work plans and timelines. Ensure deliverables are met.
  • Develop and maintain detailed and integrated CMC project plans to identify/communicate project interdependencies as well as critical path activities across multiple development programs
  • Provides expertise and strategic guidance to multi-functional project teams as a Pharmaceutical Development representative
  • Track project tasks and efforts associated with Pharmaceutical Development, CMC, manufacturing, quality and supply chain.
  • Interact with clinical teams to project drug needs, presentation and timing
  • Work with DS and DP department heads as well as an outsourced Clinical Supply Management to manage manufacturing scheduling and logistics
  • Facilitate CMC team meetings to drive cross-functional communication, timely and effective decision making, and successful execution of CMC objectives
  • Help foster a team culture of scientific curiosity, high productivity, ownership, and accountability

Requirements and Job Qualifications:

The successful candidate will be a confident leader with significant experience and success in project management; have a strong desire to apply Project Management skills to deliver novel medicines to improve patients’ lives; and an understanding of CMC, drug development, strategies, practices and regulatory agency expectations

  • S./ M.S./Ph.D. in pharmacology, chemistry, biochemistry or a related discipline.
  • Minimum of 8 years of pharmaceutical/biotechnology project management experience.
  • Minimum of 4 year’s hands-on expertise in drug development as well as managing research performed at external CROs.
  • Experience with late stage development highly desirable
  • Experience with IND, NDA, IMPD and MAA filings is desirable
  • Excellent writing and language skills along with strong communication and team management skills
  • The ability to adapt to a fast-paced environment and meet aggressive timelines
  • Exceptional organizational and interpersonal skills as well as an ability to drive results through influencing others are a must
  • Strong detail orientation and driven to achieve
  • A strong knowledge of program budget processes

To apply, please send your résumé/CV and cover letter to hr@rapharma.com.

Head of Preclinical Development

Job Code HPD2017

Ra Pharmaceuticals is a growing biotech company headquartered in Cambridge, Massachusetts. Ra is focused on novel therapeutics for dysfunction of the Complement cascade in rare diseases. The company was founded on a macrocyclic peptide platform although the pipeline has matured to include both macrocycles and traditional small molecule approaches to inhibition of the Complement cascade.

Ra Pharmaceuticals has successfully delivered its most mature project, RA101495, a macrocyclic peptide inhibitor of C5, into phase II and completed a successful IPO in October 2016. The emerging pipeline consists of several projects reaching candidate selection in 2017 (Factor D for rare systemic renal disorders and/or dry AMD, an extended release version of RA101495), as well as two projects in lead identification / lead optimization (C1 inhibitor and oral small molecule C5 inhibitor projects)

As our pipeline matures, we are looking to strengthen our Preclinical Development group by recruiting key leadership and consolidating the functions of safety/toxicology and DMPK. Therefore, we are currently recruiting for a Head of Preclinical Development, with salary and title commensurate with experience. The ideal candidate is expected to have a strong core understanding of toxicology, immunotoxicity, ADME and pharmacokinetics derived from either direct line leadership of one or several of these functions or significant experience in leading projects into clinical development.

As a senior member of the R&D Leadership Team, this position will be expected to be a key contributor to developing Ra’s pipeline. As such, this individual, will work seamlessly from research into clinical development working closely with clinical functions and regulatory.

Responsibilities:

  • Build and lead a preclinical development team to head count target of 6-8 FTEs in 2017. Thereafter, assess portfolio needs and requirement for further additional FTE 2018+.
  • Lead toxicology and DMPK to oversee all non-clinical studies required for regulatory filings, clinical stage testing and product approval.
  • Oversight of IND-enabling PK/PD, Modeling and Simulation.
  • Leadership of the stage-appropriate development and implementation of bioassays for preclinical and clinical studies.
  • As a member of the R&D Leadership team, provide oversight and guidance to all R&D activities in the company and ongoing input to the Executive Leadership team
  • Provide strategic and hands-on management ensuring that toxicology studies are conducted in line with the appropriate regulatory guidelines and standards (FDA, WHO, GLP, and ISO).
  • Oversight of Preclinical Development budget. Initiate and manage contracts in conjunction with finance group, coordinates activities with select Contract Research Organizations (CROs) and academic collaborators for preclinical development in the areas of toxicology, pharmacology, pharmacokinetics.
  • Prepare reports, regulatory documents and INDs.
  • Work closely with other functional areas and colleagues to ensure all studies are performed in a quality, timely and scientific manner.
  • Provide preclinical expertise, and strategy, to multi-functional project teams as the preclinical representative.
  • Ensure compliance with GCP, GMP, and regulatory guidelines as appropriate.

Requirements and Qualifications:

The successful candidate will be a confident leader with rigorous scientific intellect and standards. The successful candidate will have significant prior success in building and leading Preclinical Research organizations and developing novel medicines that progress through development, ideally to approval and commercialization, and possessing the following qualifications:

  • D. in pharmacology, physiology or related discipline.
  • Minimum of 12 years of pharmaceutical/biotechnology industry experience.
  • Minimum of 7 year’s hands-on expertise developing and managing preclinical studies including those performed at external CROs.
  • Mastery of preclinical drug development, strategies, practices and FDA regulations.
  • Experience with biologics and related immunological studies required.
  • Demonstrated proficiency in nonclinical study design and management.
  • Demonstrated results in preclinical development and a track record of successful IND, NDA and BLA filings.
  • Previous experience and success with choosing and managing relations with external contractors, including CROs.
  • Experience interacting with U.S. and European regulatory authorities.
  • Experience with all phases of clinical development, including pre-IND through Phase IV programs and associated regulatory filings.
  • Excellent writing and language skills along with strong communication and team management skills.
  • The ability to adapt to a fast-paced environment and meet aggressive timelines
  • Strong leadership and interpersonal skills; The individual should have a track record of developing teams and participating in developing culture and people across an organization.

To apply, please send your résumé and cover letter to hr@rapharma.com.

Director Project Management

Job Code DPM2017

Overview

Ra Pharma is looking to strengthen its project management capabilities with the appointment of a Director of Project Management. The person in this role is responsible for the generation and maintenance of integrated project plans and for ensuring optimal execution of cross-functional project activities required to progress projects toward decision points. The scope of the role is broad and encompasses both clinical development projects and earlier stage R&D projects.

Responsibilities:

  • Manage cross functional project teams in partnership with project leaders, with a particular focus on phase II and phase III development of our lead project, RA101495.
  • Responsible for the generation and maintenance of the integrated project plans for all R&D projects, including risk management, opportunities identification, timelines and budget tracking.
  • Responsible for ensuring execution of all cross-functional project activities; Identify activities on the critical path; assure continuous consistency with project strategy.
  • Work with team members to identify key issues to bring to the project team for decisions, and work to resolve conflicts in activities, budget or timelines.
  • Organize project team meetings and issue meeting minutes.
  • Manage cross functional input for resource and operational planning.
  • Responsible for the operational and financial management of clinical trial planning and execution for all projects.

Requirements

  • Advanced degree preferred.
  • PMP (Project Management Professional) certification desirable.
  • Minimum 5 years of experience in project or clinical trial management, with proven ability to manage and/or coordinate projects from start to completion.
  • Experience managing and forecasting budgets.
  • Good computer skills with ability to understand and assess technology alternatives and implication for current processes.
  • Intermediate to Advanced user skills in MS Project, Excel, Word, PowerPoint and Outlook.
  • Demonstrated leadership skills, change management, and risk/crisis management.
  • High degree of organizational, analytical, and team management and leadership skills.
  • Ability to work on complex, multi-faceted projects.
  • Excellent interpersonal skills, including strong communication skills and “customer service” orientation.
  • Strong written, oral & presentation skills, with an ability to make professional and credible first impressions with internal and external customers.
  • Excellent cross-functional collaboration skills.
  • Knowledge of ICH guidelines and FDA regulations related to drug development.

To apply, please send your résumé and cover letter to hr@rapharma.com.

Assistant Controller

Job Code FAC2017

Ra Pharmaceuticals is a clinical stage Biotechnology Company with a platform that enables the discovery of novel therapeutics. Ra Pharma combines novel insights into complement and other innate immunity pathways with leadership in macrocycle technology to transform the lives of patients with life threatening disorders. Our primary clinical focus is on diseases of complement dysregulation and orphan indications defined by validated biomarkers.

Description:

Reporting to the Controller, the Assistant Controller will be a key contributor in building a dynamic accounting and finance organization dedicated to financial integrity and focused on supporting our growth strategy.

Responsibilities:

  • Assist with the quarterly and annual process for filing the Form 10-Q and 10-K (Edgar and XBRL), including drafting and reviewing documents, ensuring quality while administering to strict timelines.
  • Assist with other periodic SEC documents, including, but not limited to Form 8-K, S-3, S-8 and Section 16 reporting requirements.
  • Ensure that the Company’s public financial statements and other SEC filings are of the highest standards of quality, GAAP compliant and useful to management and the investing public.
  • Assist with press releases, including investor presentations.
  • Manage annual process for filing the financial statements and Form 5500 for the Company’s 401K plan.
  • Assist with the implementation of the Company’s SOX compliance program, including design and initial testing of internal controls by an outside firm.
  • Ensure completeness and timelines of the Company’s SOX compliance documentation.
  • Monitor the adequacy of design and the effectiveness of execution of the control framework to ensure that it sufficiently mitigates the risk over financial reporting operations, compliance, and information technology.
  • Assist with the financial close process; from coordination and communication of the close calendar through delivery of financial results to all stakeholders.
  • Provide technical accounting support to the finance organization.
  • Update/implement accounting policies and procedures to respond to changes in the Company’s business, and SEC/GAAP regulations.
  • Assist with the implementation of a new general ledger system (NetSuite) and other IT initiatives.
  • Identify process improvements and assist in the implementation of related processes and controls.
  • Perform all other related duties as assigned.

Requirements:

The ideal candidate will be a motivated self-starter with a strong work ethic and the ability to work well in a team environment. The position requires a deadline-driven individual with attention to detail who can handle confidential information sensitively.

  • Strong accounting and financial leadership experience of 7+ years total experience, including significant time in Public Accounting. Experience with a Big Four certified public accounting firm is highly preferred.
  • Experience in a development-stage biotechnology is highly preferred.
  • Experience with the SEC compliance issues of a public company.
  • Detailed knowledge of the Sarbanes-Oxley Act, including JOBS Act requirements, specifically Section 404, and an ability to drive the Company’s compliance with all relevant accounting and certification requirements.
  • Strong technical accounting acumen and well versed in U.S. GAAP, and SEC reporting.
  • Financial (IT) systems experience.
  • Aptitude for planning/managing deadlines.
  • Exceptional communication skills, including the ability to effectively present information to various levels of an organization.
  • Strong commitment to a team approach and awareness of team and individual success dependencies.
  • Creative approach to problem solving and the ability to think “out-of the box.”
  • Ability to self-motivate and function independently, driven towards superior effort and performance and the desire to work in a very dynamic environment.

PROFESSIONAL QUALIFICATIONS

  • Bachelor’s degree in accounting or finance plus an MBA or equivalent post-graduate qualifications.
  • Active CPA certification and experience in public accounting.
  • A minimum of 6 year of experience in roles of increasing responsibility in the finance and accounting functions of a high-growth company, including responsibility for financial

accounting, SEC reporting and internal management reporting.

PERSONAL CHARACTERISTICS

  • Unquestionable integrity and personal ethics.
  • Sound business judgment.
  • Ability to listen, negotiate, guide and facilitate.
  • Ability to lead and operate effectively in a team-oriented business.
  • Tireless work ethic. Must be tenacious, with the emotional intelligence to know when to push harder and when to look for alternative approaches.
  • Confident and self-aware with excellent interpersonal and communication skills, both written and verbal. Capable of quickly establishing credibility.
  • Intelligent, with excellent analytical and strategic skills. Good business judgment and problem solving skills.
  • Extremely well organized and objective oriented.
  • Excellent relationship building and communication skills and the ability to work effectively in a team environment.

Salary and Title commensurate with experience. Please submit cover letter and resume to hr@rapharma.com.

Senior Clinical Trial Manager (Sr. CTM), Clinical Operations

Job Code SCTM 2017

Ra Pharma is a clinical stage biopharmaceutical company that combines expertise in complement biology with proven leadership in peptide chemistry to transform the lives of patients with serious and life-threatening disorders. Ra’s proprietary peptide chemistry discovery engine identifies drug candidates that combine the diversity and specificity of antibodies with the favorable pharmacological properties of small molecules. Our primary clinical focus is on rare diseases associated with complement dysregulation.

Description: Ra Pharma is seeking an experienced and energetic candidate to join their growing Clinical Operations team. This candidate will report directly to the Senior Director, Head of Clinical Operations. The Sr. CTM will be responsible for overseeing all aspects of clinical trial activities on assigned studies. This will include managing outside vendors in the execution of clinical trials and development of relationships between the Sponsor and site personnel.

RESPONSIBILITIES:

The Sr. CTM will be responsible for a broad scope of varying activities to support department and corporate goals. Primary responsibilities for this position are to:

  • Plan and implement clinical research studies within budget and on schedule.
  • Manage activities of vendors and investigators to ensure compliance with the study protocol and overall clinical objectives.
  • Coordinate and lead study team meetings and update the Clinical Team on timelines and milestones for the study.
  • Contribute to the development of study documentation including protocol review, creating study manuals, ICFs, and designing CRFs.
  • Participate in study site selection; review and update site specific consent forms; track patient accrual and study progress via standard reports; assure patient eligibility; document protocol deviations/violations; and manage adverse event reporting.
  • Oversee clinical monitoring from site qualification to site closure visits and assure integrity of clinical data with respect to accuracy, accountability and documentation through review of case report forms, source documents, and medical records. Evaluate and analyze clinical data.
  • Provide input to Clinical Study Reports and Investigator Brochures, including data cleaning, listing review, and report writing.
  • Review and negotiate contracts.
  • Ensure that study documentation is maintained according to applicable regulations, industry accepted standards, and SOPs that govern clinical studies both in the field and in-house.
  • Develop SOPs, work instructions, and standardized forms to define Clinical Operations processes within a small but growing team.
  • Collaborate with Clinical, Regulatory, and Quality team members to ensure compliance of department/study activities with FDA regulations, guidelines, and principles of ICH GCP and company SOPs.
  • Limited travel possible to field sites to supervise and/or monitor clinical studies (<20%).

QUALIFICATIONS: The ideal candidate should have a minimum of 5 years industry experience. Experience in rare diseases is highly desirable. The candidate must have a BA/BS degree or equivalent in a health science field. The candidate will have strong oral and written communication skills with monitoring, study management, and SOP-development experience. The ideal candidate will be highly adaptable, proactive, deadline- and detail-oriented, and will maintain a high level of professional expertise through recent industry training and familiarity with clinical research publications. Quality (GCP) and/or Data Management experience is a plus. The candidate will work independently under general direction in a fast-paced environment.

Please resume and cover letter to HR@rapharma.com

Head of Formulation Development Senior Scientist or Associate Director

Job Code FD 2017

Company Description

Ra Pharmaceuticals (NASDAQ RARX), a clinical-stage biopharmaceutical company based in Cambridge MA, is focused on the discovery, development and commercialization of novel therapeutics based on its proprietary peptide chemistry platform. Ra is developing therapeutics to treat serious diseases that are caused by excessive or uncontrolled activation of the complement system, a critical component of the immune system. Ra Pharmaceuticals is assembling a team of highly motivated and experienced professionals who are committed to improving the lives of patients and building a world class biotechnology company.

Position Description

Ra is currently looking for a Formulation Development Senior Scientist or Associate Director to lead the formulation development efforts for our preclinical and clinical drug development programs. This role will be responsible for parenteral formulation development as well as oral small molecule and peptide formulation development. Responsibilities also include dosage form preparation for preclinical studies. The Formulation Development Leader will draw upon sound scientific principles to direct formulation development activities while also demonstrating the organizational skills necessary for documenting activities and clearly presenting data, study findings, and rationale for the development path forward. This function works closely with Ra cross functional groups as well as external service providers including Process Development and drug product GMP Manufacturing. Working collaboratively with other scientists and disciplines (pharmacology, chemistry, pharmaceutical development, toxicology and clinical) this role will develop formulations and establish a robust Drug Product stability profile.   This individual will work across multiple project teams and be a central formulation resource in the company.

Experience with the following is highly desirable:

  • Parenteral dosage form development (subcutaneous)
  • Formulating highly lipophilic and/or lipid molecules
  • Authoring formulation relevant regulatory filing sections
  • Process development and process/technology transfer
  • Working with Contract Research/Manufacturing Organizations
  • Forced degradation and stability studies

Requirements

  • A MS or PhD degree in Chemistry or a closely related subject
  • At least 6 years of pharmaceutical development experience with focus on drug product development
  • Demonstrated ability and direct hands-on experience with developing parenteral formulations. Experience with developing subcutaneous sustained release formulations is highly desirable.
  • Successful development of formulations for clinical evaluation. Late stage formulation development highly desirable
  • Demonstrated ability and direct hands-on experience with developing highly lipophilic small molecule formulations. Experience with liquid fill capsules (such as soft gelatin capsules) is highly desirable.
  • Experience with GLP/GMP requirements during clinical development and registration
  • Excellent organizational, writing, communication and negotiation skills with a proven track record of being self-directed while managing multiple projects
  • Proven ability to work in a cross-functional, matrixed, and collaborative environment
  • Proven ability to effectively manage external manufacturing organizations / collaborators
  • Ability to thrive and develop in a biotechnology culture
  • Execute studies and research with a sense of urgency with ability to adhere to strategic program objectives while also operating/directing hands-on R&D activities.

Please resume and cover letter to HR@rapharma.com

Formulation Development Research Associate

Job Code FDRA 2017

Company Description

Ra Pharmaceuticals (NASDAQ RARX), a clinical-stage biopharmaceutical company based in Cambridge MA, is focused on the discovery, development and commercialization of novel therapeutics based on its proprietary peptide chemistry platform. Ra is developing therapeutics to treat serious diseases that are caused by excessive or uncontrolled activation of the complement system, a critical component of the immune system. Ra Pharmaceuticals is assembling a team of highly motivated and experienced professionals who are committed to improving the lives of patients and building a world class biotechnology company.

Position Description

We are currently looking for a Formulation Development Research Associate to assist the formulation development efforts for our clinical and preclinical drug development programs. Working closely with the Formulation Development Group Leader, the successful candidate will assist in the development of pharmaceutical products by performing preformulation and formulation screening experiments, as well as preparing materials for preclinical studies. Under general supervision, the candidate will work collaboratively with other scientists and disciplines (pharmacology, chemistry, pharmaceutical development, toxicology and clinical operations) to develop and prepare drug product test formulations for preclinical evaluation. You will be expected to have excellent documentation skills and be able to summarize all activities and data to allow for experimental reproducibility and communicating the supporting rationale. Most importantly the successful candidate will be self-motivated, capable of working independently and creatively under general supervision; able to follow instructions, generate data that can be traceable and substantiated, and assist with writing reports and data summaries. As needed, the candidate may assist other departments/disciplines such as Analytical Development with method development, sample prep, analysis, etc. Additionally, the candidate may support in drug product process development studies, process optimization, scale up and tech transfer to 3rd party CMO’s.

Job Responsibilities:

  • Under minimal supervision, follows methods for the production and testing of new sub-cutaneous and oral formulations, technologies and products.
  • Assists with new product scale-up, process optimization, technology transfer and process validation activities.
  • Generates data to support the development of manufacturing procedures and product specifications. Write, review, and edit technical documents.
  • Maintains an accurate, timely, and GLP compliant laboratory notebook.
  • Participate in and contribute at team meetings.

Requirements

  • BS/MS in pharmaceutics, biochemistry, chemistry or a related discipline and up to 4-6 years of experience in a research, development or manufacturing environment working with formulation or analytical development. Experience with general laboratory procedures such as buffer preparation, reagent preparation as well as good documentation skills.
  • Aseptic technique desirable
  • Motivated and able to work with minimal supervision
  • Able to solve technical problems with enthusiasm in a team environment
  • Able to function with general instructions on routine work, detailed instructions on new assignments.
  • Good written and oral communication skills.
  • Ability to thrive and develop in a biotechnology culture
  • Execute studies and research with a sense of urgency and attention to detail

Please send resume and cover letter to hr@rapharma.com