Open Positions

Analytical Development

JOB CODE: PD52018

Ra Pharmaceuticals, Inc. (NASDAQ: RARX), is a clinical stage biotechnology company focused on development of novel therapeutics for the treatment of serious diseases that are caused by dysregulation of the complement system, a critical component of the immune system. Ra Pharma combines its expertise in the area of complement biology with leadership in macrocycle peptide technology to discover and develop therapeutics that transform the lives of patients with life threatening disorders.

Description:  We are currently seeking resourceful and motivated individuals to join our team.  There are openings at the Associate and Scientist level available.  This candidate will have a supportive role in Analytical Development and will apply his/her knowledge to manage/review reference standard/stability analysis, develop analytical methods, and design experiments.  This person will also be responsible for supporting in-house analytical requirements including, but not limited to, solubility screening, forced degradation studies, small molecule and peptide purification, non-GMP stability studies and formulation development studies, and materials release.   Based upon experience, the candidate may oversee outsourced analytical method development, technical transfers, reference standard certification, GMP stability studies and material release.

Qualifications: The ideal candidate will have a BS/MS in Analytical or Organic chemistry or a closely related field and 3-5+ years of industry experience in analytical development or quality control/stability program with a proven track record of strong knowledge in stability program and developing and troubleshooting analytical methods.  Previous experience in managing/reviewing stability studies and reference standards data, characterizing and quantifying peptides, analytical method validation is preferred.  The successful candidate must be able to thrive and develop in a dynamic biotechnology start-up environment, to complete tasks with a sense of urgency, and to have a passion for scientific excellence.

Requirements:

  • BS/MS in Analytical or Organic chemistry or a related field
  • 3 to 5+ years of industry experience
  • Experience with GMP stability data review, peptides, small molecule and/or protein analytical method development including:
    • HPLC and UPLC methodology (reverse phase, size exclusion, ion exchange)
    • GC Methodology
    • Mass Spectroscopy (Quad, Q-tof and Q-Exactive).
    • Preparative Chromatography
    • QC wet chemistry
  • General familiarity with USP and EP compendial methods
  • Drive to solve problems and ability to work independently
  • Strong multi-tasking skills.
  • Excellent communication and writing skills

To apply, please send resume and cover letter to hr@rapharma.com.

Formulation Development Scientist

Job Code FDRA 2018

Position Description

We are currently looking for a Formulation Development Research Associate / Scientist to assist in the formulation development efforts for our clinical and preclinical drug development programs.  Working closely with the Formulation Development Group Leader, the successful candidate will assist in the development of pharmaceutical drug products by performing preformulation and formulation screening experiments, as well as preparing materials for preclinical studies.  Under general supervision, the candidate will work collaboratively with other scientists and disciplines (pharmacology, chemistry, pharmaceutical development, toxicology and clinical operations) to develop and prepare drug product test formulations for preclinical evaluation.  You will be expected to have excellent documentation skills and be able to summarize all activities and data to allow for experimental reproducibility and communicating the supporting rationale.   Most importantly the successful candidate will be self-motivated, capable of working independently and creatively under general supervision; able to follow instructions, generate data that can be traceable and substantiated, and assist with writing reports and data summaries.  As needed, the candidate may assist other departments/disciplines such as Analytical Development with method development, sample prep, analysis, etc.  Additionally, the candidate may support drug product process development studies, process optimization, scale up and tech transfer to 3rd party CMO’s.

Job Responsibilities:

  • Design and develop fit for purpose preclinical formulations (traditional and enabling)
  • Coordinate and contribute to drug substance and drug product characterization and stability studies to ensure optimal formulation development and selection.
  • Under minimal supervision, follows methods for the production and testing of new sub-cutaneous and oral formulations, technologies and products.
  • Assists with new product scale-up, process optimization, technology transfer and process validation activities.
  • Generates data to support the development of manufacturing procedures and product specifications. Write, review, and edit technical documents.
  • Maintains an accurate, timely, and GLP compliant laboratory notebook.
  • Participate in and contribute at team meetings.

Requirements:

  • BS/MS degree with >10 years or PhD degree with >5 years of relevant pharmaceutical industry experience working with formulation development. Solid understanding on pharmaceutical sciences and its interplay with other relevant scientific disciplines. Experience with peptide immediate and sustained release formulation development and/or small molecule solid dosage form development. .
  • Able to solve technical problems with enthusiasm in a team environment
  • Good written and oral communication skills.
  • Ability to thrive and develop in a biotechnology culture
  • Execute studies and research with a sense of urgency and attention to detail
  • Aseptic technique desirable

Please send resume and cover letter to hr@rapharma.com

Scientist – Peptide Chemistry

Job Code PC 2018

Description: 

Ra Pharmaceuticals Medicinal Chemistry team is currently seeking an experienced, innovative chemist with abilities to generate and implement original ideas and contribute to the success of the team.

We are seeking a creative, energetic, and results-oriented individual, who possesses a track record of success. Primary responsibilities will include the design, synthesis, and characterization of libraries of macrocyclic peptides and small molecules using state of the art methods.

The candidate will be expected to work independently as part of a collaborative research team. Additional responsibilities will include working with external parties in drug discovery efforts, managing collaborations with CRO’s and supervision of junior scientists.

Qualifications:

Candidates must have a Ph.D. in Synthetic Organic Chemistry or Medicinal Chemistry.  Demonstrated experience in solution- and solid-phase peptide synthesis, multi-step small molecule synthesis and knowledge of the operation of standard laboratory instrumentation (NMR, LC-MS purification, and analysis, chromatography) is required. The successful candidate will be a flexible and careful, bench scientist, who is eager to learn new technologies and excited by the challenges and rewards of working in a highly demanding environment.

(Title and compensation will be commensurate with qualifications and experience.)

To apply, please send your résumé and cover letter to hr@rapharma.com.

Synthetic Medicinal Chemist

JOB CODE: MC2018

Our Medicinal Chemistry team is currently seeking an experienced, innovative chemist with the ability to generate and implement original ideas and contribute to the success of the team.  We are seeking a creative, energetic, and results-oriented individual, who possesses a track record of success. This individual will join a medicinal chemistry team and be required to perform synthetic organic chemistry in the laboratory at a high level as well as design and data analysis of targets and routes. The candidate will be expected to work independently as part of a collaborative research team.

Responsibilities and Expectations:

  • Multi-step organic syntheses of challenging medicinal chemistry targets within a project and documentation of experimental procedures
  • Proficiency in designing, executing and troubleshooting multi-step syntheses
  • Analysis of complex data sets and creation of design hypotheses
  • Outstanding leadership, interpersonal, communication, and time-management skills are essential
  • Active participation in discussions in medicinal chemistry team meetings to build and understand structure-activity relationships

Minimum Education & Experience Requirements: 

  • D. in synthetic organic chemistry, 3 years of industrial experience
  • Demonstrated capabilities in modern methods of synthesis and analysis
  • Knowledge of operation of standard laboratory instrumentation (NMR, LC-MS purification and analysis, chromatography)
  • Application of structure based drug design leading to advanced leads/ development candidates
  • Strong working knowledge of protein-small molecule interactions, conformational and structural analysis, experienced working closely with computational chemists and the use of computational and visualization tools
  • Good understanding of key ADME, biochemical and pharmacological principles and capable of effectively integrating these concepts into the optimization of lead compounds

Title and Salary commensurate with experience. Please send resume to hr@rapharma.com.

Scientist – Biology

Job Code: TB-1-2018

We are currently seeking a highly skilled, creative and motivated individual with a strong background in immunology to join the Biology team as a Scientist. Expertise in innate and adaptive (T cell) immunity, immune cell-endothelial cell interactions, and knowledge of autoimmune and inflammatory diseases is preferred. The candidate will be responsible for validating therapeutic targets and demonstrating efficacy of lead compounds using complex human in vitro cell models and in vivo models of disease. The candidate will also provide translational biology support to programs as they progress through clinical development.

Job responsibilities:

  • Impact biology strategy aimed at validating therapeutic targets and generating foundational data to support therapeutic indications for key compounds.
  • Independently design experimental approaches to model human disease in vitro and execute on plan and leverage team members to achieve goals as needed
  • Contribute to translational biology efforts by generating key data supporting identification of biomarkers of response predictive of disease progression and of responders to therapy
  • Design and oversee the execution of in vivo models that are conducted at CROs
  • Operate in a team-based setting and mentor lab members a needed
  • Contribute to achieving a high level of operational execution in Biology by enhancing our capabilities/technologies
  • Contribute to collaborations with academic investigators
  • Communicate data and strategy in various settings including senior leadership team and externally at conferences and/or to academic collaborators

 Qualifications: The ideal candidate will have a PhD in Immunology or closely-related field.  Postdoctoral work experience in immunology is preferred. A successful track record of conceptualizing experiments, leadership at the bench towards achieving goals and impactful communication is required. Hands-on experience in immunological cellular techniques including isolation and characterization of primary immune cells from human and animal tissues is required. An experience in thriving and delivering on goals through collaborations and team work is highly desired. The successful candidate must be able to lead, thrive and develop in a fast-paced and dynamic team environment, to complete tasks with a sense of urgency, and to have a passion for scientific excellence.

Requirements:

  • PhD in Immunology or a related field, with minimum of 2 years postdoctoral work preferred with proven track record of success that includes executing in team-based settings
  • Research experience in autoimmune and inflammatory diseases
  • Hands-on experience in immune cell isolation and characterization, multi-color flow cytometry, immune cell activation assays, and tissue culture
  • Ability to independently design, execute, and analyze experiments
  • Strong multi-tasking skills
  • Excellent communication, presentation, collaboration and organizational skills

To apply, please send resume and cover letter to hr@rapharma.com.

Manager, Regulatory Operations

Job Code: RO 2018

Manager, Regulatory Operations

Ra Pharmaceuticals, Inc. (NASDAQ: RARX), is a clinical stage biotechnology company focused on development of novel therapeutics for the treatment of serious diseases that are caused by dysregulation of the complement system, a critical component of the immune system. Ra Pharma combines its expertise in the area of complement biology with leadership in macrocycle peptide technology to discover and develop therapeutics that transform the lives of patients with life threatening disorders.

Description:  Ra Pharma is seeking an experienced and energetic person to manage, evaluate, and complete regulatory submissions consistent with company goals.  The successful candidate will be responsible for overseeing operational aspects of all regulatory submissions, ensuring that the submissions are of highest quality, delivered on-time, and within established budget. The position will also support the compilation, archiving, and tracking of regulatory submissions and correspondence interfacing with Regulatory technology and publishing partners. Emphasis will be on proper planning, management, and superior execution on all aspects of regulatory affairs operations.

RESPONSIBILITIES:

Under direction from, and in collaboration with the Director, Regulatory Affairs, the candidate will:

  • Manage document publishing for regulatory submissions from all areas of the company, in support of active INDs in eCTD format (formatting, publishing, submitting, life-cycling, and archiving sequences) such as clinical trial applications, IND/ODD annual reports, amendments; may include both paper and e-filings
  • Oversee the management of electronic and/or paper-based regulatory records
  • Provide recommendations on resource needs for regulatory operations and records management activities including the need for outsourcing (e.g., eCTD vendor, SPL vendor)
  • Provide oversight for the selection and management of any outsourced publishing and records management vendors
  • Create and manage submission plans, in conjunction with Regulatory colleagues
  • Represent Regulatory Operations in project teams to support submission planning and ensure coordination of system development activities
  • Manage selection, implementation, validation (as applicable) and maintenance of IT tools for regulatory team
  • Develop proposals for continuous improvement of internal systems and processes related to publication, submissions, and archiving of regulatory dossiers in a secure and readily-accessible manner
  • Apply knowledge of electronic publishing requirements to ensure compliance with agency submission requirements and remain current with evolving standards for electronic submissions and inform other staff of these standards

QUALIFICATIONS:

  • 5-7 years’ experience working in a Regulatory Operations environment
  • Detailed knowledge of eCTD publishing systems, EDMS technology, and publishing software
  • Experience managing EDMS, regulatory publishing systems, and tracking databases
  • Expert knowledge of Microsoft Office and Adobe Suite (MS Project is a plus)
  • Demonstrated experience and a clear understanding of submission content and format requirements
  • The ability to multitask, prioritize, and work under pressure in adhering to deadlines
  • Solid experience administering and maintaining Regulatory document authoring templates
  • Strong oral and written communication and interpersonal skills
  • Strong project management and organizational skills

Please send resume and cover letter to hr@rapharma.com

Purchasing Manager

Job Code: PM 5-2018

Company Description

Ra Pharmaceuticals, Inc. (NASDAQ: RARX), is a clinical stage biotechnology company focused on development of novel therapeutics for the treatment of serious diseases that are caused by excessive or uncontrolled activation of the complement system, a critical component of the immune system.  Ra Pharma combines its expertise in area of complement with leadership in macrocycle peptide technology to discover and develop therapeutics that transform the lives of patients with life threatening disorders.

Position Description

We are currently seeking a Purchasing Manager to be responsible for the enhancement of our procurement process, purchasing policies, procedures and requirements necessary to support a growing clinical stage company. The Purchasing manager will be responsible for the the company’s purchasing activities in accordance with Ra’s Procurement policies and guidelines. This is a hands-on position and the ability to multitask and work with others is essential. This individual will report to the Vice President, Operations.

Job Responsibilities

  • Develop and implement the overall purchasing process to support the Ra day to day operations
  • Manage system (NetSuite) implementations and upgrades and testing thereof
  • Partner with stakeholders to define and implement required guidelines and policies. Formalize procedures to ensure compliance with stated policies and controls, including audit
  • Manage purchasing process including approval and maintenance of vendor information coordination and follow up on open Purchase requisitions and orders
  • Identify and implement process improvements to enhance operational efficiency and effectiveness
  • Develop reporting tools and strategies to extend analytical capabilities into the organization.
  • Manage the order processing cycle times to ensure they meet internal business performance requirements
  • Assist the business securing competitive bids or quotes for existing goods/services as needed
  • Manage the Travel program and related resources/partners (e.g. AMEX, preferred suppliers)
  • Resolve day-to-day issues that arise relating to purchasing and contracts
  • Assist with SOX, financial and tax audits & reviews
  • As necessary train users on Ra’s procurement tools

Requirements

  • BS in Business Administration or a related discipline and a minimum of 5 years of experience in purchasing, preferably in a biotechnology environment
  • Experience with NetSuite is a must
  • Solid understanding of purchasing concepts
  • Proven experience in negotiating contracts
  • Ability to operate both strategically and tactically
  • Excellent written and oral communication skills
  • Strong interpersonal skills with the ability to work well with cross functional team member
  • Superior attention to detail and strong analytical skills
  • The ability to multitask and thrive in a fast-paced environment, be proactive and resourceful

Please send resume and cover letter to hr@rapharma.com